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Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease.

Accurate prediction of dose-dependency of Theophylline metabolism in patients a priori is not possible, but patients with very high initial clearance rates (i.

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In this review we reassess the role of theophylline in the pharmacotherapy of asthma and specifically address three pivotal questions: What are the data justifying its continued use?

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Aspirin in combination with caffeine and ephedrine has failed to acutely increase the thermic effect of food.

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If the measurements are more normal, the drug likely has cleared the airways and a diagnosis of asthma is likely.

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It is not entirely clear which condition causes the other or whether they are both due to common factors.

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Drugs that may increase ethosuximide levels include isoniazid, ritonavir, and valproic acid.

theophylline has been reported to interact with a number of drugs

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In a pharmacokinetic interaction study, coadministration of multiple dose hydrochlorothiazide to healthy volunteers receiving Fluconazole increased plasma concentrations of Fluconazole by 40%.

demonstrated that receipt of the placebo instead of theophylline was a significant risk factor

These products are not intended to diagnose, treat, cure or prevent any disease.

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Your doctor might need to test your each time the dose is changed.

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In very mild cases, bronchodilators may be used only as needed, for episodes of shortness of breath.

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Controlling asthma symptoms may decrease time lost from work or school.

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Terbutaline is considered the drug of choice in the United States, although intravenous albuterol and other β2-agonists are also available elsewhere.

Theophylline affects the cardiovascular (CV), central nervous (CN), gastrointestinal (GI), pulmonary, musculoskeletal, and metabolic systems.

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After multiple doses of theophylline, steady-state is reached in 30 to 65 hours (average 40 hours) in adults.

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Clients with peripheral vascular disease also usually have a certain amount of pain especially when the oxygen demand becomes greater than oxygen supply, such as with walking or exercising.

The lack of a reliable early marker for articular damage in pediatric patients and the uncertain causal relationship between the use of the newer fluoroquinolones (as opposed to nalidixic acid) may further complicate the question of risk-benefit.

Higher doses of this product seem to provide more benefits in women than men when taken over a four year period.

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